Pd-Catalyzed Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with Imines

被引：109

作者：

Yang, Lei ^{[1
,2
,3
,4
]}

Khan, Ajmal ^{[1
,2
]}

Zheng, Renfeng ^{[1
,2
]}

Jin, Long Yi ^{[3
,4
]}

Zhang, Yong Jian ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Key Lab Elect Insulat & Thermal Aging, Shanghai 200240, Peoples R China

[3] Yanbian Univ, Minist Educ, Key Lab Organism Resources Changbai Mt & Funct Mo, Yanji 133002, Jilin, Peoples R China

[4] Yanbian Univ, Dept Chem, Yanji 133002, Jilin, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 24期

关键词：

ALPHA-HETEROFUNCTIONALIZATION; AMINO-ACIDS; CONSTRUCTION; TRANSFORMATIONS; MONOXIDE; POTENT; ROUTE;

D O I：

10.1021/acs.orglett.5b03218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the enantioselective synthesis of beta-tertiary beta-amino alcohol derivatives through Pd-catalyzed decarboxylative cycloaddition of vinylethylene carbonates with imines was developed. By using a palladium complex generated in situ from [Pd-2(dba)(3)]center dot CHCl3 and phosphoramidite L2 as a catalyst under mild reaction conditions, the process provided 4-substituted-4-vinyloxazolidines in good to high yields with high levels of enantio- and diastereoselectivities.

引用

页码：6230 / 6233

页数：4

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