Pd-Catalyzed Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with Imines

被引：109
|
作者：
Yang, Lei [1 ,2 ,3 ,4 ]
Khan, Ajmal [1 ,2 ]
Zheng, Renfeng [1 ,2 ]
Jin, Long Yi [3 ,4 ]
Zhang, Yong Jian [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Key Lab Elect Insulat & Thermal Aging, Shanghai 200240, Peoples R China
[3] Yanbian Univ, Minist Educ, Key Lab Organism Resources Changbai Mt & Funct Mo, Yanji 133002, Jilin, Peoples R China
[4] Yanbian Univ, Dept Chem, Yanji 133002, Jilin, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 24期
关键词：
ALPHA-HETEROFUNCTIONALIZATION; AMINO-ACIDS; CONSTRUCTION; TRANSFORMATIONS; MONOXIDE; POTENT; ROUTE;
D O I：
10.1021/acs.orglett.5b03218
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the enantioselective synthesis of beta-tertiary beta-amino alcohol derivatives through Pd-catalyzed decarboxylative cycloaddition of vinylethylene carbonates with imines was developed. By using a palladium complex generated in situ from [Pd-2(dba)(3)]center dot CHCl3 and phosphoramidite L2 as a catalyst under mild reaction conditions, the process provided 4-substituted-4-vinyloxazolidines in good to high yields with high levels of enantio- and diastereoselectivities.
引用
收藏
页码：6230 / 6233
页数：4
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