Myxoid spindle cell sarcoma with ETV6-NTRK3 fusion

被引：0
|
作者：
Kyriazoglou, Anastasios [1 ]
Dimitriadis, Efhtymios [2 ]
Mahaira, Luiza [2 ]
Kotsantis, John [1 ]
Kouloulias, Vasileios [3 ]
Kontogeorgakos, Vasileios [4 ]
Psyrri, Amanda [1 ]
Agrogiannis, Georgios [5 ]
机构：
[1] Attikon Univ Hosp, Propaedeut Dept Med 2, 1 Rimini St, Athens 12462, Greece
[2] Agios Savvas Anticanc Hosp, Dept Genet, Athens, Greece
[3] Attikon Univ Hosp, Dept Radiotherapy, Chaidari, Greece
[4] Attikon Univ Gen Hosp, Dept Orthopaed Surg 1, Chaidari, Attica, Greece
[5] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pathol 1, Athens, Greece
来源：
CANCER GENETICS | 2022年 / 268卷
关键词：
NTRK alteration; Myxoid spindle cell sarcoma; ETV6; NTRK3; Sarcoma genetics; POSITIVE SOLID TUMORS; OF-THE-ART; MYXOFIBROSARCOMA; BIOLOGY; TISSUE;
D O I：
10.1016/j.cancergen.2022.09.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myxoid spindle cell sarcoma is a rare sarcoma with a demanding histopathologic diagnosis due to the absence of pathognomic immunohistochemistry markers. Genetics include complex karyotypic alterations without characteristic molecular abnormalities for this entity. NTRK alterations are rare findings with great clinical importance since they can be therapeutically targeted with two NTRK inhibitors. Herein we present a case of an adult unclassified myxoid spindle cell sarcoma with ETV6/NTRK3 fusion gene, which is a molecular finding characteristic for infantile fibrosarcoma. (c) 2022 Elsevier Inc. All rights reserved.
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页码：1 / 4
页数：4
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