Myxoid spindle cell sarcoma with ETV6-NTRK3 fusion

被引：0

作者：

Kyriazoglou, Anastasios ^{[1
]}

Dimitriadis, Efhtymios ^{[2
]}

Mahaira, Luiza ^{[2
]}

Kotsantis, John ^{[1
]}

Kouloulias, Vasileios ^{[3
]}

Kontogeorgakos, Vasileios ^{[4
]}

Psyrri, Amanda ^{[1
]}

Agrogiannis, Georgios ^{[5
]}

机构：

[1] Attikon Univ Hosp, Propaedeut Dept Med 2, 1 Rimini St, Athens 12462, Greece

[2] Agios Savvas Anticanc Hosp, Dept Genet, Athens, Greece

[3] Attikon Univ Hosp, Dept Radiotherapy, Chaidari, Greece

[4] Attikon Univ Gen Hosp, Dept Orthopaed Surg 1, Chaidari, Attica, Greece

[5] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pathol 1, Athens, Greece

来源：

CANCER GENETICS | 2022年 / 268卷

关键词：

NTRK alteration; Myxoid spindle cell sarcoma; ETV6; NTRK3; Sarcoma genetics; POSITIVE SOLID TUMORS; OF-THE-ART; MYXOFIBROSARCOMA; BIOLOGY; TISSUE;

D O I：

10.1016/j.cancergen.2022.09.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myxoid spindle cell sarcoma is a rare sarcoma with a demanding histopathologic diagnosis due to the absence of pathognomic immunohistochemistry markers. Genetics include complex karyotypic alterations without characteristic molecular abnormalities for this entity. NTRK alterations are rare findings with great clinical importance since they can be therapeutically targeted with two NTRK inhibitors. Herein we present a case of an adult unclassified myxoid spindle cell sarcoma with ETV6/NTRK3 fusion gene, which is a molecular finding characteristic for infantile fibrosarcoma. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：1 / 4

页数：4

共 50 条

[1] Spindle cell tumour of the liver with an ETV6-NTRK3 fusion
Nann, D.
Bonzheim, I.
Scharpf, M.
Fend, F.
VIRCHOWS ARCHIV, 2020, 477 : S39 - S39
[2] GENE TARGETS OF ETV6-NTRK3 FUSION
MacLeod, A. F.
Chen, S.
Schneider, B.
Nagel, S.
Kaufmann, M.
Drexler, H. G.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 116 - 116
[3] A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
Stevan R. Knezevich
Deborah E. McFadden
Wen Tao
Jerian F. Lim
Poul H.B. Sorensen
Nature Genetics, 1998, 18 : 184 - 187
[4] ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma
Punnett, HH
Tomczak, EZ
Pawel, BR
de Chadarevian, JP
Sorensen, PHB
MEDICAL AND PEDIATRIC ONCOLOGY, 2000, 35 (02): : 137 - 139
[5] A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
Knezevich, SR
McFadden, DE
Tao, W
Lim, JF
Sorensen, PHB
NATURE GENETICS, 1998, 18 (02) : 184 - 187
[6] A novel ETV6-NTRK3 gene fusion in primary renal fibrosarcoma
Jiang, H.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2022, 26 (13) : 4705 - 4708
[7] Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors
Bourgeois, JM
Knezevich, SR
Mathers, JA
Sorensen, PHB
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2000, 24 (07) : 937 - 946
[8] ETV6-NTRK3 oncofusion variant interactomes
Kinnunen, Matias
Liu, Xiaonan
Niemela, Elina
Ohman, Tiina
Gawriyski, Lisa
Salokas, Kari
Keskitalo, Salla
Varjosalo, Markku
MOLECULAR & CELLULAR PROTEOMICS, 2022, 21 (08) : S70 - S70
[9] Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST
Brenca, Monica
Rossi, Sabrina
Polano, Maurizio
Gasparotto, Daniela
Zanatta, Lucia
Racanelli, Dominga
Valori, Laura
Lamon, Stefano
Dei Tos, Angelo Paolo
Maestro, Roberta
JOURNAL OF PATHOLOGY, 2016, 238 (04): : 543 - 549
[10] Expression of the ETV6-NTRK3 gene fusion in human secretory breast carcinoma
Makretsov, N
Huntsman, D
Tognon, C
Melnik, N
Sorensen, PHB
LABORATORY INVESTIGATION, 2003, 83 (01) : 297A - 297A

← 1 2 3 4 5 →