Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

被引：33

作者：

Hart, Terance ^{[1
]}

Macias, Alba T. ^{[1
]}

Benwell, Karen ^{[1
]}

Brooks, Teresa ^{[1
]}

D'Alessandro, Jalanie ^{[1
]}

Dokurno, Pawel ^{[1
]}

Francis, Geraint ^{[1
]}

Gibbons, Ben ^{[2
]}

Haymes, Timothy ^{[2
]}

Kennett, Guy ^{[2
]}

Lightowler, Sean ^{[2
]}

Mansell, Howard ^{[2
]}

Matassova, Natalia ^{[1
]}

Misra, Anil ^{[2
]}

Padfield, Anthony ^{[2
]}

Parsons, Rachel ^{[1
]}

Pratt, Robert ^{[2
]}

Robertson, Alan ^{[1
]}

Walls, Steven ^{[1
]}

Wong, Melanie ^{[1
]}

Roughley, Stephen ^{[1
]}

机构：

[1] Vernalis R&D Ltd, Cambridge CB21 6GB, England

[2] Vernalis R&D Ltd, Winnersh RG41 5UA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 15期

关键词：

FAAH; fatty acid amide hydrolase; Azetidine; Urea; Inhibitor; ENZYME;

D O I：

10.1016/j.bmcl.2009.05.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase ( FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4241 / 4244

页数：4

共 50 条

[41] Dual soluble Epoxide Hydrolase (sEH) and Fatty Acid Amide Hydrolase (FAAH) inhibitors for treating
Kodani, Sean
Wagner, Karen
Hwang, Sung Hee
Lee, Kin
Morisseau, Christophe
Hammock, Bruce
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
[42] The fatty acid amide hydrolase (FAAH)
Ueda, N
Puffenbarger, RA
Yamamoto, S
Deutsch, DG
CHEMISTRY AND PHYSICS OF LIPIDS, 2000, 108 (1-2) : 107 - 121
[43] The fatty acid amide hydrolase (FAAH)
Deutsch, DG
Ueda, N
Yamamoto, S
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2002, 66 (2-3): : 201 - 210
[44] Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases
Pillarisetti, Sivaram
Alexander, Christopher W.
Khanna, Ish
DRUG DISCOVERY TODAY, 2009, 14 (23-24) : 1098 - 1111
[45] ENOL CARBAMATES AS A NEW CLASS OF REVERSIBLE INHIBITORS OF FATTY ACID AMIDE HYDROLASE
Gattinoni, Sonia
De Simone, Chiara
Dallavalle, Sabrina
Fezza, Filomena
Minetti, Patrizia
Caprioli, Antonio
Borsini, Franco
Cabri, Walter
Penco, Sergio
Merlini, Lucio
Maccarrone, Mauro
DRUGS OF THE FUTURE, 2009, 34 : 90 - 90
[46] Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)
Lodola, Alessio
Castelli, Riccardo
Mor, Marco
Rivara, Silvia
EXPERT OPINION ON THERAPEUTIC PATENTS, 2015, 25 (11) : 1247 - 1266
[47] Structure-activity relationships of α-ketooxazole inhibitors of fatty acid amide hydrolase
Hardouin, Christophe
Kelso, Michael J.
Romero, F. Anthony
Rayl, Thomas J.
Leung, Donmienne
Hwang, Inkyu
Cravatt, Benjamin F.
Boger, Dale L.
JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (14) : 3359 - 3368
[48] Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase
Minkkila, Anna
Saario, Susanna M.
Kasnanen, Heikki
Leppanen, Jukka
Poso, Antti
Nevalainen, Tapio
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (22) : 7057 - 7060
[49] Identification of a potent, noncovalent series of fatty acid amide hydrolase (FAAH) inhibitors
Ma, Zhihua
Gustin, Darin J.
Li, Yihong
Hedberg, Christine
Min, Xiaoshan
Guimaraes, Cris
Wang, Zhulun
Lindstrom, Michelle
Porter, Amy
Lester-Zeiner, Dianna
Kayser, Frank
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[50] Predicting the Binding of Fatty Acid Amide Hydrolase Inhibitors by Free Energy Perturbation
Saha, Arjun
Shih, Amy Y.
Mirzadegan, Taraneh
Seierstad, Mark
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2018, 14 (11) : 5815 - 5822

← 1 2 3 4 5 →