Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

被引：33

作者：

Hart, Terance ^{[1
]}

Macias, Alba T. ^{[1
]}

Benwell, Karen ^{[1
]}

Brooks, Teresa ^{[1
]}

D'Alessandro, Jalanie ^{[1
]}

Dokurno, Pawel ^{[1
]}

Francis, Geraint ^{[1
]}

Gibbons, Ben ^{[2
]}

Haymes, Timothy ^{[2
]}

Kennett, Guy ^{[2
]}

Lightowler, Sean ^{[2
]}

Mansell, Howard ^{[2
]}

Matassova, Natalia ^{[1
]}

Misra, Anil ^{[2
]}

Padfield, Anthony ^{[2
]}

Parsons, Rachel ^{[1
]}

Pratt, Robert ^{[2
]}

Robertson, Alan ^{[1
]}

Walls, Steven ^{[1
]}

Wong, Melanie ^{[1
]}

Roughley, Stephen ^{[1
]}

机构：

[1] Vernalis R&D Ltd, Cambridge CB21 6GB, England

[2] Vernalis R&D Ltd, Winnersh RG41 5UA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 15期

关键词：

FAAH; fatty acid amide hydrolase; Azetidine; Urea; Inhibitor; ENZYME;

D O I：

10.1016/j.bmcl.2009.05.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase ( FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4241 / 4244

页数：4

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