Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder

被引：0

作者：

Oruc, L

Verheyen, GR

Furac, I

Jakovljevic, M

Ivezic, S

Raeymaekers, P

Van Broeckhoven, C

机构：

[1] UNIV ANTWERP VIB, DEPT BIOCHEM,NEUROGENET LAB, BORN BUNGE FDN, B-2610 ANTWERP, BELGIUM

[2] UNIV ZAGREB, SCH MED, DEPT CHEM & BIOCHEM, NEUROCHEM LAB, ZAGREB 41001, CROATIA

[3] UNIV ZAGREB, HOSP REBRO, DEPT PSYCHIAT, ZAGREB 41000, CROATIA

[4] UNIV ZAGREB, SCH MED, PSYCHIAT HOSP VRAPCE, ZAGREB 41001, CROATIA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1997年 / 74卷 / 05期

关键词：

genetics; association; mood disorders; serotonin transporter gene; serotonin receptor 2c gene;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes, No significant associations were found in the total patient sample, However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women, (C) 1997 Wiley-Liss, Inc.

引用

页码：504 / 506

页数：3

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