Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder

被引：0
|
作者：
Oruc, L
Verheyen, GR
Furac, I
Jakovljevic, M
Ivezic, S
Raeymaekers, P
Van Broeckhoven, C
机构：
[1] UNIV ANTWERP VIB, DEPT BIOCHEM,NEUROGENET LAB, BORN BUNGE FDN, B-2610 ANTWERP, BELGIUM
[2] UNIV ZAGREB, SCH MED, DEPT CHEM & BIOCHEM, NEUROCHEM LAB, ZAGREB 41001, CROATIA
[3] UNIV ZAGREB, HOSP REBRO, DEPT PSYCHIAT, ZAGREB 41000, CROATIA
[4] UNIV ZAGREB, SCH MED, PSYCHIAT HOSP VRAPCE, ZAGREB 41001, CROATIA
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS | 1997年 / 74卷 / 05期
关键词：
genetics; association; mood disorders; serotonin transporter gene; serotonin receptor 2c gene;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes, No significant associations were found in the total patient sample, However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women, (C) 1997 Wiley-Liss, Inc.
引用
收藏
页码：504 / 506
页数：3
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