Regulation of the Immune Response to α-Gal and Vector-borne Diseases

被引：32

作者：

Cabezas-Cruz, Alejandro ^{[1
]}

Mateos-Hernandez, Lourdes ^{[2
]}

Perez-Cruz, Magdiel ^{[1
]}

Valdes, James J. ^{[3
]}

Fernandez de Mera, Isabel G. ^{[2
]}

Villar, Margarita ^{[2
]}

de la Fuente, Jose ^{[2
,4
]}

机构：

[1] Univ Lille Nord France, Inst Pasteur Lille, CNRS UMR 8204, CIIL,INSERM U1019, Lille, France

[2] IREC CSIC UCLM JCCM, SaBio Inst Invest Recursos Cineget, Ciudad Real 13005, Spain

[3] Acad Sci Czech Republ, Inst Parasitol, Ctr Biol, CR-37005 Ceske Budejovice, Czech Republic

[4] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA

来源：

TRENDS IN PARASITOLOGY | 2015年 / 31卷 / 10期

关键词：

RED MEAT; ANTI-GALACTOSE-ALPHA-1,3-GALACTOSE IGE; DELAYED ANAPHYLAXIS; HOST DEFENSES; TICK BITES; ANTI-GAL; ALLERGY; GALACTOSE-ALPHA-1,3-GALACTOSE; SENSITIZATION; TRANSMISSION;

D O I：

10.1016/j.pt.2015.06.016

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Gal alpha 1-3Gal beta 1-(3)4GIcNAc-R (alpha-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-alpha-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of alpha-gal. Establishing the source of alpha-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.

引用

页码：470 / 476

页数：7

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