Alternative haematopoietic stem cell sources for transplantation: place of umbilical cord blood

被引：81

作者：

Smith, Angela R. ^{[1
]}

Wagner, John E. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pediat, Div Pediat Hematol Oncol Blood & Marrow Transplan, Sch Med, Minneapolis, MN 55455 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2009年 / 147卷 / 02期

关键词：

stem cell transplantation; umbilical cord blood; alternative stem cell sources; BONE-MARROW-TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; FANCONI-ANEMIA PATIENTS; LYMPHOMA WORKING PARTY; ACUTE MYELOID-LEUKEMIA; RISK-FACTOR ANALYSIS; UNRELATED DONORS; PEDIATRIC-PATIENTS; EUROPEAN GROUP; NONMALIGNANT DISEASES;

D O I：

10.1111/j.1365-2141.2009.07828.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Umbilical cord blood has rapidly become a valuable alternative stem cell source for allogeneic haematopoietic stem cell transplantation. Extensive research over the last 20 years has established the safety and efficacy of umbilical cord blood transplantation in both children and adults with a variety of malignant and non-malignant diseases. This research has clearly shown that this stem cell source has several unique characteristics resulting in distinct advantages and disadvantages when compared to transplantation with unrelated bone marrow or peripheral blood stem cells. This article reviews the most recent literature comparing the outcomes after umbilical cord blood transplantation with other alternative stem cell sources.

引用

页码：246 / 261

页数：16

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