Microwave-assisted synthesis of 2,4,5-triaryl-imidazole;: a novel thermally induced N-hydroxyimidazole N-O bond cleavage

被引：92
|
作者：
Sparks, RB [1 ]
Combs, AP [1 ]
机构：
[1] Incyte Corp, Expt Stn, Discovery Chem, Wilmington, DE 19880 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 14期
关键词：
D O I：
10.1021/ol049124x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,4,5-Triaryl-imidazoles were synthesized directly from the keto-oxime in moderate to good yields via cyclization to the N-hydroxyimidazole and an unprecedented in situ thermal reduction of the N-O bond upon microwave irradiation at 200 degreesC for 20 min.
引用
收藏
页码：2473 / 2475
页数：3
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