Microwave-assisted synthesis of 2,4,5-triaryl-imidazole;: a novel thermally induced N-hydroxyimidazole N-O bond cleavage

被引：92

作者：

Sparks, RB ^{[1
]}

Combs, AP ^{[1
]}

机构：

[1] Incyte Corp, Expt Stn, Discovery Chem, Wilmington, DE 19880 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 14期

关键词：

D O I：

10.1021/ol049124x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,4,5-Triaryl-imidazoles were synthesized directly from the keto-oxime in moderate to good yields via cyclization to the N-hydroxyimidazole and an unprecedented in situ thermal reduction of the N-O bond upon microwave irradiation at 200 degreesC for 20 min.

引用

页码：2473 / 2475

页数：3

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