Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy

被引：55

作者：

Pfeufer, A

Osterziel, K

Urata, H

Borck, G

Schuster, H

Wienker, T

Dietz, R

Luft, FC

机构：

[1] FRANZ VOLHARD CLIN,D-13122 BERLIN,GERMANY

[2] HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1996年 / 78卷 / 03期

关键词：

D O I：

10.1016/S0002-9149(96)00296-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the insertion/deletion polymorphism in the angiotensin- converting enzyme gene and identified polymorphisms in the heart chymase gene to test the hypothesis that these angiotensin II-producing enzymes are associated with a monogenic cardiac disease (50 patients and 50 control subjects) as a model of cardiac hypertrophy. We found that the angiotensin- converting enzyme DD genotype was present more often in patients than in control subjects and identified a possible interaction with 1 of the chymase polymorphisms.

引用

页码：362 / 364

页数：3

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