Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy

被引：55
|
作者：
Pfeufer, A
Osterziel, K
Urata, H
Borck, G
Schuster, H
Wienker, T
Dietz, R
Luft, FC
机构：
[1] FRANZ VOLHARD CLIN,D-13122 BERLIN,GERMANY
[2] HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1996年 / 78卷 / 03期
关键词：
D O I：
10.1016/S0002-9149(96)00296-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We examined the insertion/deletion polymorphism in the angiotensin- converting enzyme gene and identified polymorphisms in the heart chymase gene to test the hypothesis that these angiotensin II-producing enzymes are associated with a monogenic cardiac disease (50 patients and 50 control subjects) as a model of cardiac hypertrophy. We found that the angiotensin- converting enzyme DD genotype was present more often in patients than in control subjects and identified a possible interaction with 1 of the chymase polymorphisms.
引用
收藏
页码：362 / 364
页数：3
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