An innovative approach for microdosimetry analysis in boron neutron capture therapy

被引：0
|
作者：
Lu, XQ [1 ]
Kiger, WS [1 ]
机构：
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02115 USA
来源：
RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY | 2002年
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Due to the short-range of the charged particles emitted in BNCT, the biological effects are strongly affected by the microscopic heterogeneity of the absorbed dose distribution. Three-dimensional (3D) dosimetry information at the cellular level is required for this study. An ideal approach would be 3D reconstruction of the cell and B-10 microdistribution obtained from sequential tissue autoradiography sections. This is however impractical. An approach presented here allows estimation of the microscopic dose distribution without 3D reconstruction by using individual 2D tissue sections with a 2D to 3D correction. As an example, a data set from our laboratory is analyzed. The result was verified by a Monte Carlo simulation.
引用
收藏
页码：605 / 608
页数：4
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