A convenient and efficient one-pot method for the synthesis of novel acridine-calix[4] arene derivatives as new DNA binding agents via multicomponent reaction

被引：10

作者：

Mirza-Aghayan, Maryam ^{[1
]}

Yarmohammadi, Masoud ^{[1
]}

Zadmard, Reza ^{[1
]}

Boukherroub, Rabah ^{[2
]}

机构：

[1] CCERCI, Tehran, Iran

[2] Univ Lille 1, USR 3078, IRI, F-59658 Villeneuve Dascq, France

来源：

SUPRAMOLECULAR CHEMISTRY | 2014年 / 26卷 / 5-6期

关键词：

DNA binding agent; multicomponent reaction; fluorescence titration; acridine-calix[4]arene derivatives; POTENTIAL ANTITUMOR AGENTS; LARGE CALIXARENE DIMERS; MAJOR GROOVE BINDERS; MOLECULES; 9-ANILINOACRIDINES; INTERCALATORS; RECOGNITION;

D O I：

10.1080/10610278.2013.832763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by H-1 NMR, C-13 NMR and HR-MS. Our binding studies between acridine-functionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA. A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by H-1 NMR, C-13 NMR and HR-MS. Our binding studies between acridine-functionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA.

引用

页码：442 / 449

页数：8

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