Evaluation of mercaptoalkyl derivatives of imidazolidine-4-one as potential antioxidants and free radical scavengers

被引：0
|
作者：
KiecKononowicz, K [1 ]
Robak, J [1 ]
机构：
[1] JAGIELLONIAN UNIV, COLL MED, KATEDRA FARMAKOL, PL-31531 KRAKOW, POLAND
来源：
FARMACO | 1996年 / 51卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mercaptoalkyl derivatives of 5,5-diphenyl- and 5-arylidene hydantoins were synthesized as the result of hydrolytic cleavage of bicyclic imidazothiazoles,-thiazines, and -thiazepines. The title compounds were evaluated as potential antioxidants and free radical scavengers using the enzymic generation of O-2- and non-enzymic lipid peroxidation tests. Examined compounds were inactive in both applied tests, where reference substances (flavonoids, nitric oxide donors and Ticlopidine) inhibited non-enzymic lipid peroxidation and scavenged superoxide anions.
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收藏
页码：819 / 824
页数：6
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