Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions

被引：53
|
作者：
Chen, Liang-An [1 ]
Lear, Alan R. [1 ]
Gao, Pin [2 ]
Brown, M. Kevin [1 ]
机构：
[1] Indiana Univ, Dept Chem, 800 E Kirkwood Ave, Bloomington, IN 47405 USA
[2] Xi An Jiao Tong Univ, MOE Key Lab Nonequilibrium Synth & Modulat Conden, Xian Key Lab Sustainable Energy Mat Chem, Dept Chem,Sch Sci, Xian 710049, Shaanxi, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 32期
基金：
美国国家卫生研究院;
关键词：
alkenes; arylboration; boron; cross coupling; nickel; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE BORATION; REGIOSELECTIVE ARYLBORATION; ASYMMETRIC-SYNTHESIS; TERTIARY; ESTERS; CARBOBORATION; ALKENES; HYDROBORATION; BORYLATION;
D O I：
10.1002/anie.201904861
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the construction of boron-substituted quaternary carbons or diarylquaternary carbons by arylboration of highly substituted alkenylarenes is presented. A wide range of alkenes and arylbromides can participate in this reaction thus allowing for a diverse assortment of products to be prepared. In addition, a solvent dependent regiodivergent arylboration of 1,2-disubstituted alkenylarenes is presented, thus greatly increasing the scope of products that can be accessed.
引用
收藏
页码：10956 / 10960
页数：5
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