Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria

被引：14

作者：

Hillmen, Peter ^{[1
]}

Muus, Petra ^{[2
]}

Szer, Jeffrey ^{[3
,4
]}

Hill, Anita ^{[5
]}

Hoechsmann, Britta ^{[6
,7
]}

Kulasekararaj, Austin

Risitano, Antonio M. ^{[8
,9
]}

Van Den Neste, Eric ^{[10
]}

Liljeholm, Maria ^{[11
]}

Ebrahim, Kurt S. ^{[12
]}

Bedrosian, Camille L. ^{[13
]}

Gao, Xiang ^{[13
]}

Ames, Donna ^{[13
]}

Socie, Gerard ^{[14
]}

机构：

[1] St James Univ Hosp, Sect Expt Haematol, Level 6,Wellcome Trust Brenner Bldg,Beckett St, Leeds LS9 7TF, W Yorkshire, England

[2] Radboud Univ Nijmegen, Med Ctr, Dept Hematol, NL-6525 ED Nijmegen, Netherlands

[3] Royal Melbourne Hosp, Dept Clin Haematol, Melbourne, Vic, Australia

[4] Royal Melbourne Hosp, BMT Serv, Melbourne, Vic, Australia

[5] Leeds Teaching Hosp, St James Inst Oncol, Dept Haematol, Leeds, W Yorkshire, England

[6] Univ Ulm, Inst Clin Transfus Med & Immunogenet Ulm, Inst Transfus Med, German Red Cross Blood Transfus Serv Baden Wurtte, D-89069 Ulm, Germany

[7] Univ Hosp Ulm, Ulm, Germany

[8] Kings Coll Hosp London, London, England

[9] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[10] Clin Univ UCL St Luc, Dept Hematol, Brussels, Belgium

[11] Univ Umea Hosp, Dept Hematol, S-90185 Umea, Sweden

[12] New England Canc Specialists, Scarborough, ME USA

[13] Alex Pharmaceut Inc, Cheshire, CT USA

[14] Hosp St Louis, AP HP Hematol, Paris, France

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2016年 / 91卷 / 03期

关键词：

COMPLEMENT INHIBITOR ECULIZUMAB; IMMUNOGENICITY;

D O I：

10.1002/ajh.24280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E16 / E17

页数：2

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