Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes

被引：25

作者：

Liu, Hongwu ^{[1
]}

Yang, Jian ^{[1
,2
]}

Wang, Letian ^{[1
]}

Xu, Yungen ^{[1
]}

Zhang, Siyuan ^{[1
]}

Lv, Jie ^{[1
]}

Ran, Chongzhao ^{[2
]}

Li, Yuyan ^{[1
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China

[2] Harvard Med Sch, Massachusetts Gen Hosp, Mol Imaging Lab,MIT, Athinoula Martinos Ctr Biomed Imaging,Dept Radiol, Charlestown, MA 02129 USA

来源：

FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 02期

关键词：

Alzheimer's disease; amyloid cascade hypothesis; near-IR fluorescence imaging; IN-VIVO DETECTION; ALZHEIMERS-DISEASE FOCUS; BODIPY DYES; CROSS-LINKING; THIOFLAVIN-T; STYRYL DYES; CONGO RED; TAU; CURCUMIN; AGGREGATION;

D O I：

10.4155/fmc-2016-0185

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Evidence indicated that shifting treatment to a presymptomatic stage may produce significant benefits to prevent/alleviate the progression of Alzheimer's disease (AD); in particular, early incorporation of noninvasive imaging and biomarker testing will be significantly beneficial for AD drug development. Based on amyloid cascade hypothesis and its revised version, both beta-amyloid deposition and soluble oligomeric species could be good diagnostic biomarkers for AD. Near-IR fluorescence (NIRF) imaging, which so far is limited to animal studies, is a promising method for its incomparable advantages such as low cost, high-throughput and easy operation. This review focuses on recent reported NIRF probes that showed excellent binding to plaques and oligomers. We hope that this review will shed light on the future of NIRF probes' discovery.

引用

页码：179 / 198

页数：20

共 50 条

[41] NEAR-IR IMAGING OBSERVATIONS OF THE COMETARY IMPACT INTO JUPITER
TAKEUCHI, S
HASEGAWA, H
WATANABE, J
YAMASHITA, T
ABE, M
HIROTA, Y
NISHIHARA, E
OKUMURA, S
MORI, A
GEOPHYSICAL RESEARCH LETTERS, 1995, 22 (12) : 1581 - 1584
[42] Multispectral near-IR reflectance and transillumination imaging of teeth
Chung, Soojeong
Fried, Daniel
Staninec, Michal
Darling, Cynthia L.
BIOMEDICAL OPTICS EXPRESS, 2011, 2 (10): : 2804 - 2814
[43] NEAR-IR IMAGING OF ATHEROMAS IN LIVING ARTERIAL TISSUE
CASSIS, LA
LODDER, RA
ANALYTICAL CHEMISTRY, 1993, 65 (09) : 1247 - 1256
[44] Near-IR oxazine fluorophores for live cell imaging
Pauff, Steven
Miller, Stephen C.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
[45] Recent Progress in Small-Molecule Near-IR Probes for Bioimaging
Li, Jun-Bin
Liu, Hong-Wen
Fu, Ting
Wang, Ruowen
Zhang, Xiao-Bing
Tan, Weihong
TRENDS IN CHEMISTRY, 2019, 1 (02): : 224 - 234
[46] New directions in near-IR fluorescence detection for capillary electrophoresis
Soper, SA
Flanagan, JH
Legendre, BL
Williams, DC
Hammer, RP
ULTRASENSITIVE BIOCHEMICAL DIAGNOSTICS, PROCEEDINGS OF, 1996, 2680 : 134 - 145
[47] Assessment of tissue viability by near-IR spectroscopy and imaging
Sowa, MG
Payette, JR
Stranc, MF
Abdulrauf, B
Hewko, MD
Mansfield, JR
Mantsch, HH
INFRARED SPECTROSCOPY: NEW TOOL IN MEDICINE, PROCEEDINGS OF, 1998, 3257 : 199 - 207
[48] Near-IR luminescent neodymium complexes: spectroscopic probes for hydroamination catalysis
Bennett, Stacey D.
Pope, Simon J. A.
Ward, Benjamin D.
CHEMICAL COMMUNICATIONS, 2013, 49 (54) : 6072 - 6074
[49] Progress of Near-Infrared Fluorescent Probes for β-Amyloid Plaques in the Brain
Li Yu-Ying
Cui Meng-Chao
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2019, 47 (10) : 1524 - 1536
[50] Purified and Oxidized Single-Walled Carbon Nanotubes as Robust Near-IR Fluorescent Probes for Molecular Imaging
Movia, Dania
Del Canto, Elisa
Giordani, Silvia
JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (43): : 18407 - 18413

← 1 2 3 4 5 →