Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes

被引：25

作者：

Liu, Hongwu ^{[1
]}

Yang, Jian ^{[1
,2
]}

Wang, Letian ^{[1
]}

Xu, Yungen ^{[1
]}

Zhang, Siyuan ^{[1
]}

Lv, Jie ^{[1
]}

Ran, Chongzhao ^{[2
]}

Li, Yuyan ^{[1
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China

[2] Harvard Med Sch, Massachusetts Gen Hosp, Mol Imaging Lab,MIT, Athinoula Martinos Ctr Biomed Imaging,Dept Radiol, Charlestown, MA 02129 USA

来源：

FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 02期

关键词：

Alzheimer's disease; amyloid cascade hypothesis; near-IR fluorescence imaging; IN-VIVO DETECTION; ALZHEIMERS-DISEASE FOCUS; BODIPY DYES; CROSS-LINKING; THIOFLAVIN-T; STYRYL DYES; CONGO RED; TAU; CURCUMIN; AGGREGATION;

D O I：

10.4155/fmc-2016-0185

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Evidence indicated that shifting treatment to a presymptomatic stage may produce significant benefits to prevent/alleviate the progression of Alzheimer's disease (AD); in particular, early incorporation of noninvasive imaging and biomarker testing will be significantly beneficial for AD drug development. Based on amyloid cascade hypothesis and its revised version, both beta-amyloid deposition and soluble oligomeric species could be good diagnostic biomarkers for AD. Near-IR fluorescence (NIRF) imaging, which so far is limited to animal studies, is a promising method for its incomparable advantages such as low cost, high-throughput and easy operation. This review focuses on recent reported NIRF probes that showed excellent binding to plaques and oligomers. We hope that this review will shed light on the future of NIRF probes' discovery.

引用

页码：179 / 198

页数：20

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