Direct analysis of valsartan or candesartan in human plasma and urines by on-line solid phase extraction coupled to electrospray tandem mass spectrometry

被引：34
|
作者：
Levi, Mikael [2 ]
Wuerzner, Gregoire [3 ,4 ,5 ]
Ezan, Eric
Pruvost, Alain [1 ]
机构：
[1] CEA Saclay, DSV iBiTec S SPI, F-91191 Gif Sur Yvette, France
[2] SPI BIO, F-78180 Montigny Le Bretonneux, France
[3] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France
[4] Univ Paris 05, Fac Med, F-75006 Paris, France
[5] INSERM, CIC 9201, F-75015 Paris, France
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2009年 / 877卷 / 10期
关键词：
On-line solid phase extraction; Mass spectrometry; High throughput; Valsartan; Candesartan; II-RECEPTOR ANTAGONISTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; RENIN-ANGIOTENSIN SYSTEM; HIGH-THROUGHPUT ANALYSIS; CLINICAL PHARMACOKINETICS; FLUOROMETRIC DETECTION; BIOLOGICAL-FLUIDS; ION SUPPRESSION; VALIDATION; DRUGS;
D O I：
10.1016/j.jchromb.2009.02.030
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
AT1 receptor blockers are agents for the treatment of hypertension. Rapid and precise assay methods are needed to evaluate possible sub- or overdosage. A direct on-line solid phase extraction coupled to tandem mass spectrometry was developed and validated to determine valsartan (5-2000 ng/mL) or candesartan (1-200 ng/mL) in human plasma and urines. Both intra- and inter-assay accuracy and precision were in the range 89.2-111% and 0.9-16.9% RSD. Total run time was 4.5 min. This on-line clean-up-MS method Was found to be robust for the analysis of a high number of samples with unvarying performance. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：919 / 926
页数：8
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