Synthesis and antibacterial activity test of 3-(3-(4-hydroxy-3-methylphenyl)akriloil) coumarin compounds

A 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin has been synthesized from 4-hydroxy-3-methylbenzaldehyde with 3-acetylcoumarin. This research includes the synthesis of 4-hydroxy-3-metilbenzaldehid from ortho-cresol through Reimer-Tiemann reaction, synthesis of 3-acetylcoumarin from salicylaldehyde, synthesis of 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin, and antibacterial activity testing of 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin compound against Escherichia coli (gram negative bacteria) and Staphylococcus aureus (gram positive bacteria) using the disc diffusion method. The result of Reimer-Tiemann reaction was obtained as a yellow solid of 4-hydroxy-3-methylbenzaldehyde with yield of 31.91%. The synthesis of 3-acetylcoumarin was obtained as a yellow solid with a yield of 95.57%. A 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin was obtained as a brownish yellow solids with yield of 11.66%. A 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin has better antibacterial activity than 3-acetylcoumarin compound against Escherichia coli and Staphylococcus aureus.