Synthesis and antibacterial activity test of 3-(3-(4-hydroxy-3-methylphenyl)akriloil) coumarin compounds

被引：0
|
作者：
Ismiyarto [1 ]
Rafi'ah, Fida Hidayatul [1 ]
Rizky, Novianita [1 ]
Prasetya, Nor Basid Adiwibawa [1 ]
Sarjono, Purbowatiningrum Ria [1 ]
Ngadiwiyana [1 ]
机构：
[1] Diponegoro Univ, Fac Sci & Math, Dept Chem, Semarang, Indonesia
来源：
13TH JOINT CONFERENCE ON CHEMISTRY (13TH JCC) | 2019年 / 509卷
关键词：
Reimer-Tiemann Reaction; 3-acetylcoumarin derivatives; Antibacterial;
D O I：
10.1088/1757-899X/509/1/012055
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin has been synthesized from 4-hydroxy-3-methylbenzaldehyde with 3-acetylcoumarin. This research includes the synthesis of 4-hydroxy-3-metilbenzaldehid from ortho-cresol through Reimer-Tiemann reaction, synthesis of 3-acetylcoumarin from salicylaldehyde, synthesis of 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin, and antibacterial activity testing of 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin compound against Escherichia coli (gram negative bacteria) and Staphylococcus aureus (gram positive bacteria) using the disc diffusion method. The result of Reimer-Tiemann reaction was obtained as a yellow solid of 4-hydroxy-3-methylbenzaldehyde with yield of 31.91%. The synthesis of 3-acetylcoumarin was obtained as a yellow solid with a yield of 95.57%. A 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin was obtained as a brownish yellow solids with yield of 11.66%. A 3-(3-(4-hydroxy-3-methylphenyl) acryloyl) coumarin has better antibacterial activity than 3-acetylcoumarin compound against Escherichia coli and Staphylococcus aureus.
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页数：9
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