Adipose Tissue as an Endocrine Organ

被引：155
|
作者：
McGown, Christine [1 ]
Birerdinc, Aybike [1 ,2 ]
Younossi, Zobair M. [1 ,2 ,3 ]
机构：
[1] George Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA
[2] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA
[3] Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA USA
来源：
CLINICS IN LIVER DISEASE | 2014年 / 18卷 / 01期
关键词：
Obesity; Adipose tissue; Endocrine; Hypoxia; Inflammation; Insulin resistance; FATTY LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; MORBIDLY OBESE WOMEN; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; GENE-EXPRESSION; TNF-ALPHA; NONALCOHOLIC STEATOHEPATITIS; ENDOTHELIAL-CELLS; HEPATIC STEATOSIS;
D O I：
10.1016/j.cld.2013.09.012
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Obesity is one of the most important health challenges faced by developed countries and is increasingly affecting adolescents and children. Obesity is also a considerable risk factor for the development of numerous other chronic diseases, such as insulin resistance, type 2 diabetes, heart disease and nonalcoholic fatty liver disease. The epidemic proportions of obesity and its numerous comorbidities are bringing into focus the highly complex and metabolically active adipose tissue. Adipose tissue is increasingly being considered as a functional endocrine organ. This article discusses the endocrine effects of adipose tissue during obesity and the systemic impact of this signaling.
引用
收藏
页码：41 / +
页数：20
相关论文
共 50 条
  • [31] White Adipose Tissue as Endocrine Organ and Its Role in Obesity
    Frigolet Vazquez-Vela, Maria Eugenia
    Torres, Nimbe
    Tovar, Armando R.
    ARCHIVES OF MEDICAL RESEARCH, 2008, 39 (08) : 715 - 728
  • [32] Adipose tissue: an endocrine organ playing a role in metabolic regulation
    Booth, Andrea
    Magnuson, Aaron
    Fouts, Josephine
    Foster, Michelle T.
    HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2016, 26 (01) : 25 - 42
  • [33] Adipose tissue - From lipid storage compartment to endocrine organ
    Scherer, Philipp E.
    DIABETES, 2006, 55 (06) : 1537 - 1545
  • [34] Bone marrow adipose tissue as an endocrine organ: close to the bone?
    Sulston, Richard J.
    Cawthorn, William P.
    HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2016, 28 (01) : 21 - 38
  • [35] Adipose tissue: From lipid storage compartment to endocrine organ
    不详
    DIABETES, 2005, 54 : 7 - 7
  • [36] Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
    Martins, Fabiane Ferreira
    Souza-Mello, Vanessa
    Aguila, Marcia Barbosa
    Mandarim-de-Lacerda, Carlos Alberto
    HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2023, 44 (02) : 219 - 227
  • [37] Adipose tissue as an endocrine organ? A review of recent data related to cardiovascular complications of endocrine dysfunctions
    Pantanetti, P
    Garrapa, GGM
    Mantero, F
    Boscaro, M
    Faloia, E
    Venarucci, D
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2004, 26 (04) : 387 - 398
  • [38] Adipose tissue as an endocrine organ regulating growth puberty, and other physiological functions
    Pankov, YA
    BIOCHEMISTRY-MOSCOW, 1999, 64 (06) : 601 - 609
  • [39] Adipose Tissue as an Endocrine Organ Regulating Growth, Puberty, and Other Physiological Functions
    Endocrinology Research Center, Russian Academy of Medical Sciences, ul. Moskvorech'e 1, Moscow, 115478, Russia
    Biochemistry Moscow, 6 (601-609):
  • [40] Adipose tissue as an endocrine organ:: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases
    Fortuño, A
    Rodríguez, A
    Gómez-Ambrosi, J
    Frühbeck, G
    Díez, J
    JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2003, 59 (01) : 51 - 60
12345