Adipose Tissue as an Endocrine Organ

被引：155

作者：

McGown, Christine ^{[1
]}

Birerdinc, Aybike ^{[1
,2
]}

Younossi, Zobair M. ^{[1
,2
,3
]}

机构：

[1] George Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA

[2] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA

[3] Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA USA

来源：

CLINICS IN LIVER DISEASE | 2014年 / 18卷 / 01期

关键词：

Obesity; Adipose tissue; Endocrine; Hypoxia; Inflammation; Insulin resistance; FATTY LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; MORBIDLY OBESE WOMEN; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; GENE-EXPRESSION; TNF-ALPHA; NONALCOHOLIC STEATOHEPATITIS; ENDOTHELIAL-CELLS; HEPATIC STEATOSIS;

D O I：

10.1016/j.cld.2013.09.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Obesity is one of the most important health challenges faced by developed countries and is increasingly affecting adolescents and children. Obesity is also a considerable risk factor for the development of numerous other chronic diseases, such as insulin resistance, type 2 diabetes, heart disease and nonalcoholic fatty liver disease. The epidemic proportions of obesity and its numerous comorbidities are bringing into focus the highly complex and metabolically active adipose tissue. Adipose tissue is increasingly being considered as a functional endocrine organ. This article discusses the endocrine effects of adipose tissue during obesity and the systemic impact of this signaling.

引用

页码：41 / +

页数：20

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