Steroidal saponins from the whole plants of Agave utahensis and their cytotoxic activity

被引：47

作者：

Yokosuka, Akihito ^{[1
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Lab Med Pharmacognosy, Sch Pharm, Tokyo 1920392, Japan

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 06期

关键词：

Agave utahensis Engelm; Agavaceae; Spirostanol saponins; Furostanol saponins; Cytotoxic activity; HL-60; cells; UNDERGROUND PARTS; INHIBITORY-ACTIVITY; SOLANACEOUS PLANTS; GLYCOSIDES; SPIROSTANOL; METABOLISM; SAPOGENINS; RHIZOMES; CELLS;

D O I：

10.1016/j.phytochem.2009.02.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the whole plants of Agave utahensis Engelm. (Agavaceae) has resulted in the isolation of 15 steroidal saponins (1-15), including five spirostanol saponins (1-5) and three furostanol saponins (11-13). Structures of compounds 1-5 and 11-13 were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：807 / 815

页数：9

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