Developing novel activity-based fluorescent probes that target different classes of proteases

被引：35

作者：

Zhu, Q

Girish, A

Chattopadhaya, S

Yao, SQ

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 13期

关键词：

D O I：

10.1039/b404471a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this article, we report the design and synthesis of a group of novel activity-based probes that target different protease subclasses based on their substrate specificities, rather than their enzymatic mechanisms. The feasibility of our approach has been demonstrated by using representative members of the different protease sub-classes.

引用

页码：1512 / 1513

页数：2

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