Total Synthesis of (3R, 4S)-4-Hydroxylasiodiplodin via Ring Closing Metathesis Protocol

被引：5
|
作者：
Reddy, Julakanti Satyanarayana [1 ]
Manimala, Patel [1 ]
Gangababu, Marri [1 ]
Rammohan, Aluru [1 ,2 ]
Yadav, Jillu Singh [1 ]
机构：
[1] CSIR, Indian Inst Chem Technol, Ctr Semiochem, Hyderabad 500007, Telangana, India
[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 18期
关键词：
D-isoascorbic acid; Lasiodiplodin; Mitsunobu reaction; Regioselective ring opening; Ring-Closing Metathesis; FACILE TOTAL-SYNTHESIS; LASIODIPLODIN; CHEMISTRY; LACTONES;
D O I：
10.1002/slct.201900189
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Total synthesis of (3R, 4S)-4-Hydroxylasiodiplodin has been accomplished through convergent strategy using D-isoascorbic acid and trihydroxybenzoic acid as the starting materials in an optimal reaction sequence. The salient features of the synthesis are the utilization of Stille coupling, trans-esterification and Ring-Closing Metathesis (RCM).
引用
收藏
页码：5345 / 5347
页数：3
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