Total Synthesis of (3R, 4S)-4-Hydroxylasiodiplodin via Ring Closing Metathesis Protocol

被引：5

作者：

Reddy, Julakanti Satyanarayana ^{[1
]}

Manimala, Patel ^{[1
]}

Gangababu, Marri ^{[1
]}

Rammohan, Aluru ^{[1
,2
]}

Yadav, Jillu Singh ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Ctr Semiochem, Hyderabad 500007, Telangana, India

[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 18期

关键词：

D-isoascorbic acid; Lasiodiplodin; Mitsunobu reaction; Regioselective ring opening; Ring-Closing Metathesis; FACILE TOTAL-SYNTHESIS; LASIODIPLODIN; CHEMISTRY; LACTONES;

D O I：

10.1002/slct.201900189

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total synthesis of (3R, 4S)-4-Hydroxylasiodiplodin has been accomplished through convergent strategy using D-isoascorbic acid and trihydroxybenzoic acid as the starting materials in an optimal reaction sequence. The salient features of the synthesis are the utilization of Stille coupling, trans-esterification and Ring-Closing Metathesis (RCM).

引用

页码：5345 / 5347

页数：3

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