Dual-detector polarimetry for compensation of motion artifact in a glucose sensing system

Much work has been done to make the optical measurement of glucose concentrations in the aqueous humor a feasible, non-invasive, alternative for the blood finger stick method currently used by people with diabetes mellitus. Recent work has demonstrated that the time lag between blood and aqueous humor glucose levels is within five minutes but there is still work to be done in overcoming the confounding effects of changing birefringence, due to motion artifact, on the detected glucose signal during in-vivo measurements. To address this issue, we designed and implemented a dual orthogonal polarization detection system. We present promising preliminary results that indicate that this method, with some slight modifications and optimization of our system, has the potential to extract glucose concentration information from a birefringent sample in the presence of motion artifact.