One-pot lipase-catalyzed synthesis of enantiopure secondary alcohols from carbonyl compounds: a new protocol for lipase-mediated resolution

被引：48
|
作者：
Kamal, A [1 ]
Sandbhor, M [1 ]
Ramana, KV [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 08期
关键词：
D O I：
10.1016/S0957-4166(02)00170-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reduction of acetophenones with sodium borohydride in the presence of neutral alumina in hexane followed by enantioselective acylation catalyzed by Pseudomonas cepacia lipase has been achieved in one-pot. Further, immobilized lipase offered a high degree of selectivity with spontaneity. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：815 / 820
页数：6
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