Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction

被引：1074
|
作者：
Haigis, Marcia C. [1 ]
Guarente, Leonard P. [1 ]
机构：
[1] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
GENES & DEVELOPMENT | 2006年 / 20卷 / 21期
关键词：
Sir2; aging; glutamate dehydrogenase; SIRT1-7; mitochondria; insulin; calorie restriction;
D O I：
10.1101/gad.1467506
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.
引用
收藏
页码：2913 / 2921
页数：9
相关论文
共 50 条
  • [41] Calorie restriction: Oxidative stress, aging and cancer
    Weindruch, R
    FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 : S7 - S7
  • [42] Modulation of PPAR in aging, inflammation, and calorie restriction
    Sung, B
    Park, S
    Yu, BP
    Chung, HY
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2004, 59 (10): : 997 - 1006
  • [43] The effects of calorie restriction on aging: a brief review
    Al-Regaiey, K. A.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2016, 20 (11) : 2468 - 2473
  • [44] Calorie restriction and aging: The ultimate "Cleansing Diet"
    Cuervo, Ana Maria
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2008, 63 (06): : 547 - 549
  • [45] Recent advances in calorie restriction research on aging
    Chung, K. W.
    Kim, D. H.
    Park, M. H.
    Choi, Y. J.
    Kim, N. D.
    Lee, J.
    Yu, B. P.
    Chung, H. Y.
    EXPERIMENTAL GERONTOLOGY, 2013, 48 (10) : 1049 - 1053
  • [46] Brain aging and calorie restriction in rhesus macaques
    Sridharan, A.
    Kemnitz, J. W.
    Colman, R. J.
    Weindruch, R.
    Johnson, S. C.
    EXPERIMENTAL GERONTOLOGY, 2013, 48 (07) : 695 - 695
  • [47] Plasma glucose and the action of calorie restriction on aging
    McCarter, Roger
    Mejia, Walter
    Ikeno, Yuji
    Monnier, Vincent
    Kewitt, Kristen
    Gibbs, Michael
    McMahan, Alex
    Strong, Randy
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2007, 62 (10): : 1059 - 1070
  • [48] Calorie restriction and aging in rhesus monkeys Abstracts
    Kemnitz, Joseph W.
    EXPERIMENTAL GERONTOLOGY, 2015, 68 : 92 - 92
  • [49] Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens
    Budayeva, Hanna G.
    Rowland, Elizabeth A.
    Cristea, Ileana M.
    JOURNAL OF VIROLOGY, 2016, 90 (01) : 5 - 8
  • [50] Redox-regulating sirtuins in aging, caloric restriction, and exercise
    Radak, Zsolt
    Koltai, Erika
    Taylor, Albert W.
    Higuchi, Mitsuru
    Kumagai, Shuzo
    Ohno, Hideki
    Goto, Sataro
    Boldogh, Istvan
    FREE RADICAL BIOLOGY AND MEDICINE, 2013, 58 : 87 - 97
12345