Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction

被引：1074
|
作者：
Haigis, Marcia C. [1 ]
Guarente, Leonard P. [1 ]
机构：
[1] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
GENES & DEVELOPMENT | 2006年 / 20卷 / 21期
关键词：
Sir2; aging; glutamate dehydrogenase; SIRT1-7; mitochondria; insulin; calorie restriction;
D O I：
10.1101/gad.1467506
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.
引用
收藏
页码：2913 / 2921
页数：9
相关论文
共 50 条
  • [21] Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction
    Lu, Shu-Ping
    Lin, Su-Ju
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2010, 1804 (08): : 1567 - 1575
  • [22] At the crossroad of lifespan, calorie restriction, chromatin and disease Meeting on sirtuins
    Mostoslavsky, Raul
    Esteller, Manel
    Vaquero, Alejandro
    CELL CYCLE, 2010, 9 (10) : 1907 - 1912
  • [23] Application of calorie restriction and calorie restriction mimetics to attenuate brain aging
    Ingram, D. K.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [24] Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
    Tatone, Carla
    Di Emidio, Giovanna
    Barbonetti, Arcangelo
    Carta, Gaspare
    Luciano, Alberto M.
    Falone, Stefano
    Amicarelli, Fernanda
    HUMAN REPRODUCTION UPDATE, 2018, 24 (03) : 267 - 289
  • [25] Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
    Smith, Daniel L., Jr.
    McClure, Julie M.
    Matecic, Mirela
    Smith, Jeffrey S.
    AGING CELL, 2007, 6 (05) : 649 - 662
  • [26] Emerging beneficial roles of sirtuins in heart failure
    Tanno, Masaya
    Kuno, Atsushi
    Horio, Yoshiyuki
    Miura, Tetsuji
    BASIC RESEARCH IN CARDIOLOGY, 2012, 107 (04)
  • [27] Emerging beneficial roles of sirtuins in heart failure
    Masaya Tanno
    Atsushi Kuno
    Yoshiyuki Horio
    Tetsuji Miura
    Basic Research in Cardiology, 2012, 107
  • [28] Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
    Henryk Jęśko
    Przemysław Wencel
    Robert P. Strosznajder
    Joanna B. Strosznajder
    Neurochemical Research, 2017, 42 : 876 - 890
  • [29] Excessive adiposity, calorie restriction, and aging
    Fontana, L
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (13): : 1577 - 1578
  • [30] Calorie Restriction and Aging in Nonhuman Primates
    Kemnitz, Joseph W.
    ILAR JOURNAL, 2011, 52 (01) : 66 - 77
12345