Blood homocysteine and kidney involvement in type 1 and type 2 diabetes mellitus

In 215 diabetics (52 type 1, 163 type 2) patients and 60 healthy controls, tHcy was measured to check the relationships between renal status and metabolic parameters. While tHcy resulted significantly higher in micromacroalbuminuric diabetics, compared to normoalbuminurics (14.3 +/- 84.7 vs 11.1 +/- 20.3 mumol/l, p 0.002) and in low-GFR (less than or equal to 70 ml/min) versus normal -GFR patients (16.2 +/- 7.9 vs 10.3 +/- 4.2 ml/min, respectively p < 0.0001), serum creatinine and GFR proved to be the main determinants of tHcy levels in diabetics as just proved in non-diabetic people.