CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on long-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

被引：34

作者：

Greathead, Louise ^{[1
]}

Metcalf, Rebecca ^{[1
]}

Gazzard, Brian ^{[2
]}

Gotch, Frances ^{[1
]}

Steel, Alan ^{[3
]}

Kelleher, Peter ^{[2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Immunol Sect, Div Infect Dis, London SW10 9NH, England

[2] Chelsea & Westminster Hosp NHS Fdn Trust, HIV & Sexual Hlth Directorate, London, England

[3] Chelsea & Westminster Hosp NHS Fdn Trust, Dept Gastroenterol, London, England

来源：

AIDS | 2014年 / 28卷 / 11期

关键词：

HIV-INFECTION;

D O I：

10.1097/QAD.0000000000000351

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.

引用

页码：1690 / 1692

页数：3

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