CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on long-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

被引：34
|
作者：
Greathead, Louise [1 ]
Metcalf, Rebecca [1 ]
Gazzard, Brian [2 ]
Gotch, Frances [1 ]
Steel, Alan [3 ]
Kelleher, Peter [2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Immunol Sect, Div Infect Dis, London SW10 9NH, England
[2] Chelsea & Westminster Hosp NHS Fdn Trust, HIV & Sexual Hlth Directorate, London, England
[3] Chelsea & Westminster Hosp NHS Fdn Trust, Dept Gastroenterol, London, England
来源：
AIDS | 2014年 / 28卷 / 11期
关键词：
HIV-INFECTION;
D O I：
10.1097/QAD.0000000000000351
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.
引用
收藏
页码：1690 / 1692
页数：3
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