Discovery of natural mouse serum derived HIV-1 entry inhibitor(s)

被引：0

作者：

Wei, M. ^{[1
]}

Chen, Y. ^{[2
]}

Xi, J. ^{[1
]}

Ru, S. ^{[1
]}

Ji, M. ^{[1
]}

Zhang, D. ^{[1
]}

Fang, Q. ^{[3
]}

Tang, B. ^{[1
]}

机构：

[1] Bengbu Med Coll, Sch Life Sci, Inst Neurobiol, Anhui Key Lab Infect & Immun, Bengbu 233030, Peoples R China

[2] Univ Arizona, Dept Pharmacol, Coll Med, Tucson, AZ 85724 USA

[3] Bengbu Med Coll, Dept Microbiol & Parasitol, Anhui Key Lab Infect & Immun, Bengbu 233030, Peoples R China

来源：

ACTA VIROLOGICA | 2016年 / 60卷 / 04期

关键词：

HIV-1; entry; natural inhibitor; mouse serum; VIRUS; FUSION; PEPTIDE; POTENT; GP41; REPLICATION; ENFUVIRTIDE; RESISTANCE; AGONIST; CELLS;

D O I：

10.4149/av_2016_04_404

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10-25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10-25 K protein(s) is novel natural HIV-1 entry inhibitor(s). Our findings provide important information about novel natural HIV entry inhibitors in mouse serum.

引用

页码：404 / 409

页数：6

共 50 条

[31] Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry
Ugwu-Korie, Nneka
Quaye, Osbourne
Wright, Edward
Languon, Sylvester
Agyapong, Odame
Broni, Emmanuel
Gupta, Yash
Kempaiah, Prakasha
Kwofie, Samuel K.
MOLECULES, 2023, 28 (02):
[32] Blocking HIV-1 entry by a gp120 surface binding inhibitor
Tsou, Lun K.
Chen, Chin-Ho
Dutschman, Ginger E.
Cheng, Yung-Chi
Hamilton, Andrew D.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (09) : 3358 - 3361
[33] Identification of a D-amino acid decapeptide HIV-1 entry inhibitor
Boggiano, Csar
Jiang, Shibo
Lu, Hong
Zhao, Qian
Liu, Shuwen
Binley, James
Blondelle, Sylvie E.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 347 (04) : 909 - 915
[34] A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry
Herschhorn, Alon
Gu, Christopher
Espy, Nicole
Richard, Jonathan
Finzi, Andres
Sodroski, Joseph G.
NATURE CHEMICAL BIOLOGY, 2014, 10 (10) : 845 - +
[35] Highly concentrated formulations of the HIV-1 entry inhibitor PRO 542.
Prakash, K
Zhao, L
Fisch, D
Rosenfield, S
Nagashima, K
Schülke, N
Olson, W
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U231 - U232
[36] A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry
Alon Herschhorn
Christopher Gu
Nicole Espy
Jonathan Richard
Andrés Finzi
Joseph G Sodroski
Nature Chemical Biology, 2014, 10 : 845 - 852
[37] XLHX-124-50 as a potent HIV-1 entry inhibitor targeting on HIV-1 gp41 envelope
Li, Lin
Qiu, Jia-ying
Yang, Jie
Chen, Jin-quan
Zhang, Xuan-xuan
Liu, Shu-wen
ACTA PHARMACOLOGICA SINICA, 2013, 34 : 151 - 152
[38] HIV-1 entry and entry inhibitors as therapeutic agents
Starr-Spires, LD
Collman, RG
CLINICS IN LABORATORY MEDICINE, 2002, 22 (03) : 681 - +
[39] The cell biology of HIV-1 entry
Blumenthal, Robert
Finnegan, Catherine M.
Viard, Mathias
Rawat, Satinder S.
Puri, Anu
RETROVIROLOGY, 2005, 2 (Suppl 1)
[40] Stoichiometric parameters of HIV-1 entry
Zan, Melissa
Siliciano, Robert
VIROLOGY, 2015, 474 : 1 - 9

← 1 2 3 4 5 →