Discovery of natural mouse serum derived HIV-1 entry inhibitor(s)

被引：0

作者：

Wei, M. ^{[1
]}

Chen, Y. ^{[2
]}

Xi, J. ^{[1
]}

Ru, S. ^{[1
]}

Ji, M. ^{[1
]}

Zhang, D. ^{[1
]}

Fang, Q. ^{[3
]}

Tang, B. ^{[1
]}

机构：

[1] Bengbu Med Coll, Sch Life Sci, Inst Neurobiol, Anhui Key Lab Infect & Immun, Bengbu 233030, Peoples R China

[2] Univ Arizona, Dept Pharmacol, Coll Med, Tucson, AZ 85724 USA

[3] Bengbu Med Coll, Dept Microbiol & Parasitol, Anhui Key Lab Infect & Immun, Bengbu 233030, Peoples R China

来源：

ACTA VIROLOGICA | 2016年 / 60卷 / 04期

关键词：

HIV-1; entry; natural inhibitor; mouse serum; VIRUS; FUSION; PEPTIDE; POTENT; GP41; REPLICATION; ENFUVIRTIDE; RESISTANCE; AGONIST; CELLS;

D O I：

10.4149/av_2016_04_404

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10-25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10-25 K protein(s) is novel natural HIV-1 entry inhibitor(s). Our findings provide important information about novel natural HIV entry inhibitors in mouse serum.

引用

页码：404 / 409

页数：6

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