N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-β-lactamase

被引：93

作者：

Siemann, S

Evanoff, DP

Marrone, L

Clarke, AJ

Viswanatha, T

Dmitrienko, GI

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

[2] Univ Guelph, Dept Microbiol, Canadian Bacterial Dis Network, Guelph, ON N1G 2W1, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2450-2457.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-beta-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-beta-lactamase activity exhibited by this class of compounds.

引用

页码：2450 / 2457

页数：8

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