N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-β-lactamase

被引：93
|
作者：
Siemann, S
Evanoff, DP
Marrone, L
Clarke, AJ
Viswanatha, T
Dmitrienko, GI
机构：
[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada
[2] Univ Guelph, Dept Microbiol, Canadian Bacterial Dis Network, Guelph, ON N1G 2W1, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期
关键词：
D O I：
10.1128/AAC.46.8.2450-2457.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-beta-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-beta-lactamase activity exhibited by this class of compounds.
引用
收藏
页码：2450 / 2457
页数：8
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