Voltammetric DNA biosensor for the study of mechanism of action of anticancer drug-adriamycin

被引：0
|
作者：
Tiwari, Sweety [1 ]
Pitre, K. S. [1 ]
机构：
[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Chem, Sagar 470003, India
来源：
INDIAN JOURNAL OF CHEMICAL TECHNOLOGY | 2008年 / 15卷 / 06期
关键词：
Modified electrode; Biosensor; Adriamycin; Anthracycline compound;
D O I：
暂无
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The interaction of anticancer drug adr amycin with DNA has been studied using voltammetric DNA biosensor. The binding mechanism of adriamycin was elucidated by using differential pulse voltammetry (DPV) at DNA modified glassy carbon fiber electrodes (GCFE). The decrease in guanine oxidation peak current at +0.9 V was used as an indicator for interaction mechanism in acetate buffer (pH 4.5). The studied drug-DNA interaction mechanism at charged electrode surface is similar to the in-vivo DNA-drug complex formation, where DNA is in close contact with charged phospholipid membranes and proteins. Thus, the fabricated biosensor helps in understanding the in-vivo mechanism of action of this anticancer drug.
引用
收藏
页码：593 / 597
页数：5
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