Voltammetric DNA biosensor for the study of mechanism of action of anticancer drug-adriamycin

被引：0

作者：

Tiwari, Sweety ^{[1
]}

Pitre, K. S. ^{[1
]}

机构：

[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Chem, Sagar 470003, India

来源：

INDIAN JOURNAL OF CHEMICAL TECHNOLOGY | 2008年 / 15卷 / 06期

关键词：

Modified electrode; Biosensor; Adriamycin; Anthracycline compound;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The interaction of anticancer drug adr amycin with DNA has been studied using voltammetric DNA biosensor. The binding mechanism of adriamycin was elucidated by using differential pulse voltammetry (DPV) at DNA modified glassy carbon fiber electrodes (GCFE). The decrease in guanine oxidation peak current at +0.9 V was used as an indicator for interaction mechanism in acetate buffer (pH 4.5). The studied drug-DNA interaction mechanism at charged electrode surface is similar to the in-vivo DNA-drug complex formation, where DNA is in close contact with charged phospholipid membranes and proteins. Thus, the fabricated biosensor helps in understanding the in-vivo mechanism of action of this anticancer drug.

引用

页码：593 / 597

页数：5

共 50 条

[21] Redox mechanism, spectrophotometrical characterisation and voltammetric determination in serum samples of kinases inhibitor and anticancer drug dasatinib
Jesus, Catarina S. H.
Diculescu, Victor C.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2015, 752 : 47 - 53
[22] Study on the mechanism of the interaction between anticancer drug actinomycin D and calf thymus DNA by fluorescence method
Li, LS
Huang, WD
Wang, RQ
Yan, Y
ACTA CHIMICA SINICA, 1999, 57 (06) : 572 - 577
[23] HPMA copolymer-anticancer drug conjugates:: design, activity, and mechanism of action
Kopecek, J
Kopecková, P
Minko, T
Lu, ZR
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 50 (01) : 61 - 81
[24] Polymer-Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action
Pasut, Gianfranco
Greco, Francesca
Mero, Anna
Mendichi, Raniero
Fante, Cristina
Green, Rebecca J.
Veronese, Francesco M.
JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (20) : 6499 - 6502
[25] An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug
Ghoshal, K
Jacob, ST
BIOCHEMICAL PHARMACOLOGY, 1997, 53 (11) : 1569 - 1575
[26] Use of the microarrays to study the mechanism of action of new anticancer drugs
Marchini, S
Chiorino, G
MINERVA BIOTECNOLOGICA, 2001, 13 (04) : 269 - 280
[27] DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action
Palchaudhuri, Rahul
Hergenrother, Paul J.
CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (06) : 497 - 503
[28] Insights on cyclophosphamide metabolism and anticancer mechanism of action: A computational study
Dabbish, Eslam
Scoditti, Stefano
Shehata, Mohammed N. I.
Ritacco, Ida
Ibrahim, Mahmoud A. A.
Shoeib, Tamer
Sicilia, Emilia
JOURNAL OF COMPUTATIONAL CHEMISTRY, 2024, 45 (10) : 663 - 670
[29] In situ evaluation of anticancer drug methotrexate-DNA interaction using a DNA-electrochemical biosensor and AFM characterization
Rodrigues Pontinha, Ana Dora
Alves Jorge, Sonia Maria
Paquim, Ana-Maria Chiorcea
Diculescu, Victor Constantin
Oliveira-Brett, Ana Maria
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2011, 13 (12) : 5227 - 5234
[30] DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin
David-Cordonnier, MH
Gajate, C
Olmea, O
Laine, W
de la Igiesia-Vicente, J
Perez, C
Cuevas, C
Otero, G
Manzanares, I
Bailly, C
Mollinedo, F
CHEMISTRY & BIOLOGY, 2005, 12 (11): : 1201 - 1210

← 1 2 3 4 5 →