Receptor trafficking induced by μ-opioid-receptor phosphorylation

被引：11
|
作者：
Zhang, Yan [1 ]
Xiong, Wei
Lin, Xiaojing
Ma, Xiang
Yu, Long-Chuan
机构：
[1] Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2009年 / 33卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Opiates; mu-Opioid receptor; Phosphorylation; Trafficking; Tolerance; Dependence; G-protein coupled receptor kinase; RAPID DESENSITIZATION; CELLULAR MECHANISMS; MORPHINE-TOLERANCE; DOWN-REGULATION; BETA-ARRESTIN; OPIATE DRUGS; SPINAL-CORD; IN-VIVO; AGONIST; INTERNALIZATION;
D O I：
10.1016/j.neubiorev.2009.03.007
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Opiates, including morphine, are widely used drugs for antinociception in clinics. Prolonged treatments of opioids induce both tolerance and dependence, which are the major side effects of opioid therapy. One of the mechanisms for the development of tolerance and dependence is implicated to be opioid-receptor trafficking. Here we review the current understandings of opioid-receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments. Also, the role of G-protein coupled receptor kinases in opioid-receptor phosphorylation is discussed. How to associate these observations to physiological and behavioral changes in animal models and clinics is still under investigation. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1192 / 1197
页数：6
相关论文
共 50 条
  • [41] Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model
    Yuan C.-S.
    Wang C.-Z.
    Mehendale S.R.
    Aung H.H.
    Foo A.
    Israel R.J.
    AIDS Research and Therapy, 6 (1)
  • [42] IRAS Modulates Opioid Tolerance and Dependence by Regulating μ Opioid Receptor Trafficking
    Fei Li
    Hao Ma
    Ning Wu
    Jin Li
    Molecular Neurobiology, 2016, 53 : 4918 - 4930
  • [43] IRAS Modulates Opioid Tolerance and Dependence by Regulating μ Opioid Receptor Trafficking
    Li, Fei
    Ma, Hao
    Wu, Ning
    Li, Jin
    MOLECULAR NEUROBIOLOGY, 2016, 53 (07) : 4918 - 4930
  • [44] THE PROPERTY OF OPIOID-RECEPTOR SUBTYPE IN GUINEA-PIG AND MOUSE-BRAIN HOMOGENATES
    FUJISAWA, T
    ITO, H
    OKA, T
    FOLIA PHARMACOLOGICA JAPONICA, 1983, 81 (04) : P52 - P52
  • [45] Nucleocytoplasmic trafficking of the opioid growth factor receptor and opioid growth factor
    Zagon, IS
    Ruth, TB
    Leure-duPree, AE
    Sassani, JW
    McLaughlin, PJ
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 107A - 107A
  • [46] Cellular tolerance at the μ-opioid receptor is phosphorylation dependent
    Arttamangkul, Seksiri
    Heinz, Daniel A.
    Bunzow, James R.
    Song, Xianqiang
    Williams, John T.
    ELIFE, 2018, 7
  • [47] Role of Phosphorylation Sites in Desensitization of μ-Opioid Receptor
    Yousuf, Arsalan
    Miess, Elke
    Sianati, Setareh
    Du, Yan-Ping
    Schulz, Stefan
    Christie, MacDonald J.
    MOLECULAR PHARMACOLOGY, 2015, 88 (04) : 825 - 835
  • [48] Recent advances on the δ opioid receptor: from trafficking to function
    Gendron, Louis
    Mittal, Nitish
    Beaudry, Helene
    Walwyn, Wendy
    BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (02) : 403 - 419
  • [49] μ-opioid receptor trafficking on inhibitory synapses in the rat brainstem
    Browning, KN
    Kalyuzhny, AE
    Travagli, RA
    JOURNAL OF NEUROSCIENCE, 2004, 24 (33): : 7344 - 7352
  • [50] Opioid-receptor-heteromer-specific trafficking and pharmacology
    van Rijn, Richard M.
    Whistler, Jennifer L.
    Waldhoer, Maria
    CURRENT OPINION IN PHARMACOLOGY, 2010, 10 (01) : 73 - 79
12345