Receptor trafficking induced by μ-opioid-receptor phosphorylation

被引：11
|
作者：
Zhang, Yan [1 ]
Xiong, Wei
Lin, Xiaojing
Ma, Xiang
Yu, Long-Chuan
机构：
[1] Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2009年 / 33卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Opiates; mu-Opioid receptor; Phosphorylation; Trafficking; Tolerance; Dependence; G-protein coupled receptor kinase; RAPID DESENSITIZATION; CELLULAR MECHANISMS; MORPHINE-TOLERANCE; DOWN-REGULATION; BETA-ARRESTIN; OPIATE DRUGS; SPINAL-CORD; IN-VIVO; AGONIST; INTERNALIZATION;
D O I：
10.1016/j.neubiorev.2009.03.007
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Opiates, including morphine, are widely used drugs for antinociception in clinics. Prolonged treatments of opioids induce both tolerance and dependence, which are the major side effects of opioid therapy. One of the mechanisms for the development of tolerance and dependence is implicated to be opioid-receptor trafficking. Here we review the current understandings of opioid-receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments. Also, the role of G-protein coupled receptor kinases in opioid-receptor phosphorylation is discussed. How to associate these observations to physiological and behavioral changes in animal models and clinics is still under investigation. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1192 / 1197
页数：6
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