Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp.

被引：72
|
作者：
Wainwright, M [1 ]
Phoenix, DA
Gaskell, M
Marshall, B
机构：
[1] Univ Cent Lancashire, Photochemotherapy Grp, Dept Biol Sci, Preston PR1 2HE, Lancs, England
[2] Royal Preston Hosp, Publ Hlth Lab, Preston PR2 4HT, Lancs, England
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 44卷 / 06期
关键词：
D O I：
10.1093/jac/44.6.823
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The toxicities and phototoxicities of methylene blue and its two methylated derivatives were measured against one standard and three vancomycin-resistant pathogenic strains of Enterococcus spp, Each of the compounds was bactericidal and the derivatives exhibited photobactericidal activity on illumination at a 'light' dose of 6.3 J/cm(2) against one or more of the strains, Increased bactericidal and photobactericidal activity in the methylated derivatives is thought to be due to their higher hydrophobicities allowing greater interaction with the bacterial cell wall, In addition, the derivatives exhibited higher inherent photosensitizing efficacies.
引用
收藏
页码：823 / 825
页数：3
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