A brief history behind the most used local anesthetics

被引：12

作者：

Bezerra, Marco M. ^{[1
]}

Leao, Raquel A. C. ^{[1
]}

Miranda, Leandro S. M. ^{[1
]}

de Souza, Rodrigo O. M. A. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Chem Inst, Biocatalysis & Organ Synth Grp, BR-21941909 Rio De Janeiro, Brazil

来源：

TETRAHEDRON | 2020年 / 76卷 / 47期

关键词：

Anesthetics; Medicinal chemistry; Organic synthesis; Mepivacaine; ARYL HALIDES; CHEMOSELECTIVE HYDROGENATION; SELECTIVE REDUCTION; NITRO-COMPOUNDS; CATALYZED AMINATION; AROMATIC-AMINES; NITROARENES; EFFICIENT; PLATINUM; AMMONIA;

D O I：

10.1016/j.tet.2020.131628

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemistry behind the discovery of local anesthetics is a beautiful way of understanding the development and improvement of medicinal/organic chemistry protocols towards the synthesis of biologically active molecules. Here in we present a brief history based on the chemistry development of the most used local anesthetics trying to draw a line between the first achievements obtained by the use of cocaine until the synthesis of the mepivacaine analogs nowadays. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：15

共 50 条

[41] A brief history of A-MOST Special Issue containing selected papers from A-MOST 2008
Frantzen, Lars
Merayo, Mercedes G.
Nunez, Manuel
JOURNAL OF LOGIC AND ALGEBRAIC PROGRAMMING, 2009, 78 (06): : 417 - 424
[42] Dexmedetomidine: the most versatile and multitasking of anesthetics
Di Filippo, Alessandro
Romagnoli, Stefano
MINERVA ANESTESIOLOGICA, 2021, 87 (09) : 968 - 970
[43] Behind the times: a brief history of motivation discourse in problem-based learning
Lisette Wijnia
Virginie F. C. Servant-Miklos
Advances in Health Sciences Education, 2019, 24 : 915 - 929
[44] Behind the times: a brief history of motivation discourse in problem-based learning
Wijnia, Lisette
Servant-Miklos, Virginie F. C.
ADVANCES IN HEALTH SCIENCES EDUCATION, 2019, 24 (05) : 915 - 929
[45] VASOCONSTRICTORS IN LOCAL ANESTHETICS
BISHOP, JG
DORMAN, HL
MATTHEWS, JL
DENTAL CLINICS OF NORTH AMERICA, 1961, (JUL) : 279 - &
[46] LOCAL-ANESTHETICS
HEAVNER, JE
VETERINARY CLINICS OF NORTH AMERICA-LARGE ANIMAL PRACTICE, 1981, 3 (01): : 209 - 221
[47] A Brief History behind the journal Genetic Epidemiology and the International Genetic Epidemiology Society
Rao, Dabeeru C. C.
GENETIC EPIDEMIOLOGY, 2023, 47 (05) : 361 - 364
[48] EPINEPHRINE SHOULD NOT BE USED WITH LOCAL-ANESTHETICS FOR EPIDURAL-ANESTHESIA IN PREECLAMPSIA - REPLY
HELLER, PJ
ANESTHESIOLOGY, 1987, 66 (04) : 578 - 579
[49] HYPERSENSITIVITY TO LOCAL ANESTHETICS
Mascarenhas, Maria Isabel
da Silva, Susana Lopes
Mendes, Ana
Santos, Amelia Spinola
Pedro, Elisa
Barbosa, Manuel Pereira
ACTA MEDICA PORTUGUESA, 2011, 24 (02): : 293 - 298
[50] Synergism of local anesthetics
Rider, TH
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1930, 40 (01): : 7 - 22

← 1 2 3 4 5 →