A brief history behind the most used local anesthetics

被引：12
|
作者：
Bezerra, Marco M. [1 ]
Leao, Raquel A. C. [1 ]
Miranda, Leandro S. M. [1 ]
de Souza, Rodrigo O. M. A. [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Chem Inst, Biocatalysis & Organ Synth Grp, BR-21941909 Rio De Janeiro, Brazil
来源：
TETRAHEDRON | 2020年 / 76卷 / 47期
关键词：
Anesthetics; Medicinal chemistry; Organic synthesis; Mepivacaine; ARYL HALIDES; CHEMOSELECTIVE HYDROGENATION; SELECTIVE REDUCTION; NITRO-COMPOUNDS; CATALYZED AMINATION; AROMATIC-AMINES; NITROARENES; EFFICIENT; PLATINUM; AMMONIA;
D O I：
10.1016/j.tet.2020.131628
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The chemistry behind the discovery of local anesthetics is a beautiful way of understanding the development and improvement of medicinal/organic chemistry protocols towards the synthesis of biologically active molecules. Here in we present a brief history based on the chemistry development of the most used local anesthetics trying to draw a line between the first achievements obtained by the use of cocaine until the synthesis of the mepivacaine analogs nowadays. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：15
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