The authors report the presence of high titer antibodies to glutamic acid decarboxylase (anti-GAD65) until age 24 months in two asymptomatic newborns of a woman with stiff-person syndrome (SPS). No signs of SPS were detectable in the two children at ages 6 and 8 years. This observation indicates that other cofactors are involved in the pathogenesis of SPS.
机构:
Univ Athens, Dept Pathophysiol, Neuroimmunol Unit, Athens, GreeceUniv Athens, Dept Pathophysiol, Neuroimmunol Unit, Athens, Greece
Alexopoulos, Harry
Akrivou, Sofia
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Univ Athens, Dept Pathophysiol, Neuroimmunol Unit, Athens, GreeceUniv Athens, Dept Pathophysiol, Neuroimmunol Unit, Athens, Greece
Akrivou, Sofia
Dalakas, Marinos C.
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Univ Athens, Dept Pathophysiol, Neuroimmunol Unit, Athens, Greece
Thomas Jefferson Univ, Philadelphia, PA 19107 USAUniv Athens, Dept Pathophysiol, Neuroimmunol Unit, Athens, Greece
机构:
Univ Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, FinlandUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Hanninen, Arno
Soilu-Hanninen, Merja
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Univ Turku, Dept Neurol, FIN-20520 Turku, FinlandUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Soilu-Hanninen, Merja
Hampe, Christiane S.
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Univ Washington, Dept Med, Seattle, WA USAUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Hampe, Christiane S.
Deptula, Angie
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Benaroya Res Inst, Seattle, WA USAUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Deptula, Angie
Geubtner, Kelly
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机构:
Benaroya Res Inst, Seattle, WA USAUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Geubtner, Kelly
Ilonen, Jorma
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机构:
Univ Turku, Immunogenet Lab, FIN-20520 Turku, Finland
Univ Eastern Finland, Dept Clin Microbiol, Kuopio, FinlandUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Ilonen, Jorma
Knip, Mikael
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Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland
Univ Helsinki, Folkhalsan Res Ctr, Helsinki, Finland
Tampere Univ Hosp, Dept Pediat, Tampere, FinlandUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland
Knip, Mikael
Reijonen, Helena
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机构:
Benaroya Res Inst, Seattle, WA USAUniv Turku, Dept Med Microbiol & Immunol, FIN-20520 Turku, Finland