Synthesis and antimicrobial evaluation of novel pyrimidine-5-carboxamide scaffold

被引：0

作者：

Ghodasara, Hardik B. ^{[1
]}

Patel, Bharat G. ^{[1
]}

Shah, Viresh H. ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 04期

关键词：

Pyrimidine; carboxamide; antibacterial; antiftmgal; biological assay; DIHYDROPYRIMIDINES; POTENT;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis and biological evaluation of pyrimidine-5-carboxamide derivatives containing 2,4-diamino substituted derivatives have been described. Biginelli typed three component reactions between an aldehyde, malononitrile and a guanidine constituent gives a rapid facile pyrimidine ring. The constitution of the products has been delineated by elemental analysis and spectral analysis: The products have been assayed for their in vitro biological assay antibacterial activity against S. pyogens MTCC-442, S. aurues MTCC-96, E. coli MTCC-443, B. subtillitis MTCC-441 bacterial strain and antifungal activity against Aspergillus, niger MTCC-282 and Candida albicans MTCC-227 at different concentrations and compared with Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin and Griseofulvin as standard drug results of which are presented.

引用

页码：419 / 425

页数：7

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